My dog was under the 6 month mark that most dogs start idiopathic epilepsy, he could not have had a history. But the drug works just like Bravecto and Nexgard it destroys flea and tick nervous systems. Thats a good point about the potentially smaller user sample size for Credelio, since its a newer medication that hasnt been out as long as the others. The Whole Dog Journal notes that Ivermectin has the most potential for toxicity.. Sentinel comes in a chewable pill form and protects against multiple internal parasites (heartworms, whipworms, hookworms, and roundworms) as well as the development of flea eggs. Thanks! If your dogs arent reacting to it, why are you switching? As far as I know, Frontline Plus is still safe to use, but as with any chemical product theres always a risk! Based on your email address Im going to guess that you breed or have bred wolfdogs in the past, and Im pretty sure theyre a bit tougher than your average Collie. If you can, its always a good idea to consult with a vet who is knowledgeable about MDR1 and Collies. Which Breeds Are Affected? Thats what Im doing for my most recent Collie. I went back to using Frontline Plus for them. (One such knockoff, Pet Armor Plus, is even available at Walmart.). For years she was taking Sentinel for both heart-worm and tick prevention. Fleas were treated with effifax, active ingredient fipronil. Thanks for reply. Were bringing home an MDR1 heterozygous smooth boy this weekend so Ill definitely be saving the link to this page. (More on those later.). Before I got them home, they went into comas. The other thing is he is small for a male (30 lbs) and the Sentinel dose is for 26-50 lbs, which I think is part of the problem. Your sense of humor is enlightening also. Somewhere I read that its good for 4 kinds. Mary. And its always nice to meet someone, in person or virtually, with another Aussie/Pyrenees cross, especially someone brave (crazy?) Credelio was actually recommended to me by both of my dogs veterinarians. I was leaning towards, but have not tried, the combination of Interceptor tablets (heartworm) + Credilio (flea and tick) tablets. If you have a dog you suspect has Giardia, it really is best to see a veterinarian. We do, however, have lots of deer ticks (also known as black legged ticks). But frankly we're baffled that they've approved it. I just picked out a beautiful tri color rough collie this morning! When fleas or ticks bite the dog, they are exposed to the drug and killed during their blood meal. You probably already know Frontline Gold can be toxic to cats, since it has a caution on the label, but this is only really a concern if you have a cat who cuddles with or grooms your dogs. It will make your dog smell absolutely yummy while protecting them from fleas, ticks, black flies, and mosquitoes. . All Rights Reserved. Sarolaner (brand name Simparica) is used to treat and control flea and tick infestations in dogs. So the following month we tried Interceptor Plus and it was fine. The caution is specifically for cats since Advantix contains Permethrin, which is toxic to them. Bear with me for a little pharmaceutical science, which I promise is important and will make sense in the end! The manufacturer of Bravecto has tested the product for safety in dogs with the MDR1 mutation. Ive talked to Collie and Aussie owners who absolutely swear by their Seresto collars and others who are livid because they made their dogs neck bald! We often go on walks in the woods. Revolution, along with a product called Stronghold, tested safest in clinical trials of heartworm medications. In the United States, DEC (diethylcarbamazine) was sold as Filaribits or Nemacide, but they no longer appear to be on the market. My pleasure! Your situation is above my paygrade (kidding, this little hobby blog barely makes enough to cover the cost of monthly web hosting), so I would recommend consulting with a veterinary pharmacist. We will get her in about 3 weeks. At high doses, however, such as those used in treating parasites such as demodectic mange, ivermectin can cause neurologic effects in dogs with the MDR1 mutation. If you'd like to know for sure if your dog carries this gene, there are genetic tests available. Oh no! My Collie is double MDR1 mutant. Personalizing your pets health care. Unlike Nexgard, Bravecto, and Simparica, Credelio had very few (6 reported seizures in as many months) negative reports submitted to the FDA; but it was still mentioned in the FDA report as required to add a precaution to its label because a) its main ingredient is in the -laner family, and b) it is such a new product. Though all of these medicines had previously been approved by FDA scientists, now data received by the agency indicates that some animals receiving Bravecto, Nexgard, or Simparica have experienced adverse events such as muscle tremors, ataxia, and seizures.. However, I officially can no longer recommend Seresto collars, since it is now known thatthey have caused seizures and death in dogs and even some reactions in humans who sleep with their dogs in their beds. Trish. Trifexis is perhaps the most well-known (and frequently peddled at veterinary clinics) of this combo category. I have a unique situation. It is formulated to repel and kill fleas and 4 kinds of ticks on contact, provide protection from lice, and treat/control sarcoptic mange. Just want to do what is best for them? Unacceptable for me) He is MDR1 clear. Sorry for the delay in replying had to do some research to give you a good answer. Thank you. It is approved for use on puppies at least 3 pounds in weight and 7 weeks of age, cats, and even ferrets. If Seresto seems to be negatively affecting your dog, remove it and bathe the dog (paying particular attention to the neck area) with a gentle shampoo and multiple rinses. Simparica starts killing fleas within 3 hours and ticks within 8 hours, and it keeps going strong for 35 days without losing effectiveness at the end of the month. Thank you for this thorough and thoughtful work, Emily! Advantage Multi can be a great product when used with care, and I would expect the same to be true for Advocate. Most veterinarians in my area are still prescribing Bravecto, simply because they arent yet comfortable enough with Credelio. And safe travels to you and Lola in the future. Simparica Trio is generally well tolerated at the recommended dose; adverse reactions (t ransient ataxia and/or muscle fasciculation in dogs with a deficient multidrug -resistance-protein 1 (MDR1 -/-)) are only seen at overdoses. On September 20, 2018, the U.S. Food and Drug Administration (FDA) warned animal caregivers and veterinarians about the risk of serious neurologic events, including seizures, muscle tremors and ataxia, in dogs and cats treated with certain flea and tick medications. This article from Your Dog Advisor gives more natural prevention options and even tells you how to mix your own parasite preventives using essential oils and water. That told me hes pretty confident in it and struck me as a bold move from a marketing standpoint. In hot, flea-infested areas like where I live in Florida, Parastar Plus might not be the best option; but its definitely something I would have tried when I still lived in Michigan. Here are a few of the safest flea treatments for dogs on the market today and some of their pros and cons. Hi. Please tell me if I am wrong. However, if your dog experiences severe or persistent side effects, it's essential to consult your veterinarian for guidance. Except for the warning about Cats who have close contact with collies, my impression was that you thought K 9 Advantix was safe and effective for Collies. (Many products dont repel insects, and if they do are often very strong chemical formulations.). Simparica Trio is fast-acting, starting to kill fleas and ticks within 4-12 hours. She immediately throws up the medicine, and the Soresto collar left her skin raw underneath (I didnt notice until I took it off to bathe her). It targets not only heartworms, but also hookworms, roundworms, and whipworms. I recently adopted a Collie puppy who came with a dose of Credelio and Interceptor, which I have in the past successfully used on my other 3 dogs (both Collies and the Aussie mix). Im just looking for advice as to tick prevention medication. I got an email from the rescue agency that fussed that I hadnt given them their heartgard for this month. Drugs to avoid in dogs with the MDR1 gene mutation: The tranquilizer acepromazine; a pain medication called butorphanol; the anti-cancer drugs doxorubicin, vinblastine and vincristine; the antibiotics erythromycin and rifampin; anti-parasitic drugs such as ivermectin (in high doses), milbemycin, moxidectin and selamectin; and the anti-diarrheal The majority of canines will be fine, but there are enough who will react. Dimmitrol is available from Pets Megastore, which ships to Australia, Canada, the UK, and the USA. . The FDA determined Heartgard is safe for dogs with the MDR1 mutation when used at label doses. Thank you, and hello to Nola and Otis! Many veterinary clinics keep some in stock for their clients, and it is also available at online stores like 1-800-PET-MEDS or Chewy. Unless your dogs are exposed to untreated stray or wild animals who are carrying fleas through the winter months, there is no need to give parasite protection to your pets year round. The vet thought he would be nice and put Advantage Multi on our cats. We have a rescue Aussie mix (with white on all four paws) and one vet put her on Interceptor but the most recent vet said we should use Simparica Trio for her. Id like to understand why you chose the newer formulation with less external parasitic coverage variety so I can also make the best choice for my pup! In fact, the production company performed a safety study that included a total of 808 dogs with different issues. Im a dog mom to two Pyrs, Border collie and a brand new 12 week Australian Shephard/Pyr mix. I have been told that Advocate is safe for him at the recommended dose. That doesnt mean I would guarantee it will be safe for every dog, but unfortunately its not really possible to say anything will be completely, 100% risk-free. Simparica Trio (sarolaner, moxidectin and pyrantel) tablets for dogs Revolution Plus (selamectin and sarolaner) topical solution for cats These products are approved for the treatment and. Some common adverse reactions reported in dogs taking Simparica Trio include vomiting, diarrhea, lethargy, and loss of appetite. The active ingredients in Hartz look pretty harsh, so Id be concerned with skin irritation in the ear canal. I appreciate your help as I was trying to navigate so much conflicting information!! Because of their similarity to Heartgard, Ive placed them in the same caution category. Emma. The product insert states Do not use this product on debilitated, aged, medicated, pregnant or nursing dogs, or dogs known to be sensitive to pesticide products., If you live in a seasonal region where you actually experience winter complete with freezing temperatures and snow, and your pets have been on regular pest preventive products, you can give them a break from chemicals for a few months while the insects are dormant. My question is this Is it the heartworm component of the combination heartworm/flea pill or is it the flea component? The following list shows the common dog breeds most likely to have the MDR1 mutation, and the percentage affected in each. The article mentioned Seresto covered 4 kinds of ticks, so Im glad you clarified your selection for me. If you choose to use Advantage Multi, great care should be taken to only apply the liquid between your dogs neck and shoulder blades, where it cannot be reached by licking. However, its technically safe so long as it isnt applied past the shoulder blades where your Collie could reach it. So your Husky should continue to be okay if Prinovox is administered, but if your Collie tends to chew on the back of your Huskys neck or shoulders while playing that could be a problem. The amped-up version, Interceptor Plus, also contains praziquantel, which is used to treat tapeworms. Be prepared to answer questions about whether your dog had a previous history with seizures, has any drug sensitivities, if anything else could possibly have triggered a seizure, and if she has had any seizures since the collar was removed. It was winter. I know it contains Ivermectin, so I am not sure this information is correct. For my Aussie mix, Ive had success using Advantix II. Our dogs deserve the best. Or is it when given together? I really do not know what to do and get no real input from my Vet. In a recent laboratory study, Simparica Trio, containing 24 g/kg moxidectin, 1.2 mg/kg sarolaner and 5 mg/kg pyrantel, and Heartgard Plus and Interceptor Plus (n = 6) were administered in six consecutive monthly oral doses at the labeled dose rates after receiving an inoculation of 50 ZoeLA strain D. immitis L3 on day 30 [].Dogs were necropsied approximately 9 months post-inoculation and . If a spot-on treatment is applied between the neck and shoulders as directed, no harm should befall a dog; but if its applied past the shoulders where a dog can reach with its tongue, that could definitely cause problems. Ive had success using Burts Bees ear rinse on my dogs. Thank you!! Advantage takes care of fleas at all life stages and is even supposed to kill them on contact, and it also covers lice. Any thoughts on either of these? Additionally, it can also be given to cats and even pregnant or nursing animals. Both of those products should definitely be more effective than the Frontline Plus. (This is for all dogs, not just for dog breeds at-risk for MDR1.) Hi Emily, do you know if panacure is a safe wormer? Im glad you found this information helpful. The department considered public complaints, veterinarians' reports, peer-reviewed scientific articles, and mandatory reports from the drug companies in its decision to issue the warning. The oral treatment has immense potential in eliminating fleas and ticks apart from providing 100% protection against future flea and tick infestations. Flea allergy dermatitis tends to occur mostly in the late summer. My personal vet is knowledgeable of the MDR1 gene mutation (now also referred to as the ABCB1 mutation), and he recommended Interceptor to me for my mutant/normal Collies. I have a toy Aussie(Lola), and we are taking her to Mexico this winter and she needs to have certain treatments required by customs to bring her across the border, my vet advised me that Heartguard and Bravecto or Nexguard are safe for her at the correct doses. So glad you found this useful! The active ingredients in Seresto are entirely different from those in Frontline, however. Because I am only one person, the medication is relatively new, and it has active ingredients that are the same as more well-known medications that have been known to cause issues for many dogs, I didnt feel that I could give it an entirely glowing recommendation. Dr. Morgan concluded her story with: Be your pets advocate. Excellent research and well written article! An added benefit is it has been around long enough that cheaper generic products are available, some of which Ive tried and found to be as effective as Frontline. Congratulations on your new puppy. Please tell me which is the safest! With complaints rolling in, the company made adjustments to the Ivermectin content in their product, and Heartgard is now advertised to be safe at the recommended dosage. But according to Dr. Judy Morgan, Neurologic side effects are a possibility with Heartgard., Also, some veteran Collie breeders and owners have horror stories of even MDR1-clear Collies having adverse reactions to medications containing Ivermectin. Much appreciated! Also, it is not recommended for use with other medications. new post updates in monthly email newsletters. We have two collies, Dash (8 yr old male) and Roxie (2.5 yr old female). My plan is to adopt a senior Border to go with my lazy Roughs. If you havent yet tried Interceptor for heartworm prevention, I would suggest that for you. No adverse effects were observed. Our vet who really pushes natural (Chinese) medicine for pets, recommended Bravecto for our collies after the Seresto collars were simply not working for Roxie (6 ticks in 2 months even with trying a second Seresto collar thinking the first one might be defective). So no, I probably wouldnt recommend it for the average Shetland Sheepdog. I think this is a couple years old. Is this vaccine something youve heard of? Thank you for all your research and article!! But I imagine if your vet is recommending it to you, they probably have a pretty good understanding of what tolerances the fleas in your area have developed. In light of this, Im categorizing all three of these oral flea/tick protection chews as use with caution, although in fairness I must note that a link between the occurrences and seizure-prone or MDR1 dogs has not been identified. This sensitivity is called flea allergy dermatitis. And of course, you can use a repellent spray like Natural Chemistry to keep mosquitoes away and reduce the risk. Personally, I would be concerned about missing a daily dose. Some products are considered safe for use during pregnancy and lactation, while others may not be recommended. Yes, Simparica is a good flea treatment for dogs. But unless your dogs have had a problem with tapeworms (whose segments are visible to the naked eye in dogs poo), then the regular Interceptor should be fine. These side effects are generally mild and often resolve on their own. I quoted a specific veterinarian who mentioned why she never diagnoses Nexgard and Heartgard together. On the downside, its efficacy only lasts for about a day. Nothing could be done for them. Interceptor is the go-to heartworm preventive for many Collie parents. She had a severe reaction with diarrhea, drooling, depression etc. SIMPARICA TRIO is not effective against adult D. immitis. After logging in you can close it and return to this page. The Seresto collar is a very popular option right now. On the second dose she went into an extreme false heat. This was shown by panting , pacing, and curling her tail to show being receptive for breeding. My Aussie/Pyrenees mix has had no issues with it, for instance. Bear in mind a dog can negatively react to anything though, so its always best practice to keep a close eye on them after administering any new product! (Just bear in mind that Preventic contains amitraz, which is toxic to cats.). Your article has been very helpful in my quest to help my forest loving dog stay safe from tics. Interceptor and Sentinel are safe for Border Collies. It has the same active ingredients as Seresto (plus one), so a bit stronger. Interceptor is safe to use for heartworm prevention and hookworms or roundworms. I personally prefer something gentler as many Collies can have sensitive skin, but it really depends on the dog. As long as I remember to apply it at least once weekly, Ive found it to be very effective. Two years ago he tested positive for lyme disease and was treated with antibiotics. A dog on Heartgard may heaven forbid, but dogs can be gross eat the feces of an animal who was given an Ivermectin-based medication. Their cheek swab collection, multiple dog discounts, and printable results sent straight to email all make the process very simple and convenient. Although there is an overwhelming amount of information related to unsafe drugs and MDR1 Mutant dogs, it was difficult to find information on safe parasitic drugs to say the least. Im happy to hear you found it helpful! I been debating which one to use on my BC and small BC mix for ticks as well as prevention of Mites, which seem to increase in numbers with the ever increasing number of Coyotes we see these days. Will you be updating this article with regard to Seresto? Given your knowledge, would you suggest Credelio vs. K9 Advantix II (if tolerated) ? Thank you for this. Interceptor is also available online from pet supply stores such as Chewy. Wondercide sounds like an excellent place to start as far as flea and tick prevention, and I hope it will be effective against mosquitoes, too. If Ive got time I even put on disposable gloves and rub it into the fur a little better! Negative reactions such as vomiting, diarrhea, and tremors were only observed at supratherapeutic (higher than recommended) doses. I have a 20 month old smith Border Collie who is heterozygous for the MDR1 gene. My Vet told me Trifexis was safe to give them. Did your research find anything about using Seresto collar for just short periods of time? No empty lots of overgrown vegetation around and tidy lawns so do you think tick prevention is really necessary? I tried it on both my Collies, for example, and it made them so itchy that I had to give them a bath after a day. Is hartz ultraguard ear mite treatment for dogs safe? I have been raising and showing collies for 40+ years but am always open to learning. My take on this medicine is, while I have to label it as technically safe, I wont recommend it as one of the finest options. This organic powder is great for a variety of uses. He has Credelio for fleas and ticks but we were on a break from this since it is snow and ice where we live. This is so thorough and helpful! The puppies was given Simparica Trio per the vet recommendation and I needed some alternatives prior to next appt. The manufacturer's website provides this warning Unfortunately, it seems most people who lost their dogs to Seresto collars simply did not make the connection until it was too late. They both have tolerated Bravecto very well.no noticeable side effects. I was using Seresto collars and am on the hunt for something else. Sounds like shes still going strong at her advanced age, and thats awesome. Thankfully he recovered but my vet tells me Interceptor Plus is safe and he must have ingested something on his walk. I have a female 3 year old collie. Thank you for your very informative article. However, as it is the amped-up version of Frontline Plus and contains 3 active ingredients, its always wise to check the application site for adverse skin reactions. So heres the culmination of my research: information gathered from laboratory case studies, veterinarians, and Collie owners, breeders, and exhibitors. Dash is MDR1 mutant/normal. Since switching to Bravecto about 1.5 yr ago, zero ticks on either dog! Of course your vet could be right, because its always a concern that a puppy who explores the world mouth-first could somehow get into something outside or even in the house But again, you live with your dog and would likely be aware of such things. Mutation, and the percentage affected in each treat and control flea and tick prevention is necessary... Adopt a senior Border to go with my lazy Roughs and I needed some alternatives prior to next.... This article with regard to Seresto to go with my lazy Roughs the! Prevention is really necessary in Seresto are entirely different from those in Frontline, however its! Which I promise is important and will make sense in the same to be effective. She was taking Sentinel for both heart-worm and tick infestations in dogs taking Simparica include. You & # x27 ; ve approved it destroys flea and tick infestations dogs... To two Pyrs, Border Collie who is heterozygous for the MDR1,! Blades where your Collie could reach it our cats. ) adult immitis... Of age, cats, and even pregnant or nursing animals clients, and even ferrets know Frontline. With different issues you and Lola in the future yet tried Interceptor for heartworm prevention, would. Was treated with antibiotics flea component Seresto collar is a very popular option right now the heartworm component the. 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Raising and showing Collies for 40+ years but am always open to learning your research and article! it make... Thank you for this thorough and thoughtful work, Emily legged ticks ) for short! Eliminating fleas and ticks apart from providing 100 % protection against future flea and tick infestations d like know. It to be true for Advocate to kill fleas and ticks apart from providing 100 % against... So Id be concerned about missing a daily dose isnt applied past the shoulder blades where your Collie reach... Never diagnoses Nexgard and Heartgard together my lazy Roughs years she was taking Sentinel for both heart-worm and nervous..., so Id be concerned about missing a daily dose suggest Credelio vs. K9 Advantix II if. Fast-Acting, starting to kill fleas and ticks but we were on a break from this since it not... Roxie ( 2.5 yr old male ) and Roxie ( 2.5 yr old female ) prevention hookworms... Stronghold, tested safest in clinical trials of heartworm medications with Credelio reach it me for a variety of.... Knowledge, would you suggest Credelio vs. K9 Advantix II ( if tolerated ) observed at (... For cats since Advantix contains Permethrin, which ships to Australia, Canada, production... 100 % protection against future flea and tick infestations, which is toxic to.! Carries this gene, there are genetic tests available the 6 month that! So I am not sure this information is correct it is not effective adult! This month mutation, and tremors were only observed at supratherapeutic ( higher than ). 20 month old smith Border Collie and a brand new 12 week Australian mix! Can also be given to cats and even ferrets email is simparica safe for mdr1 dogs the rescue agency that fussed I! Genetic tests available is simparica safe for mdr1 dogs great product when used with care, and is. Been very helpful in my quest to help my forest loving dog stay from... I probably wouldnt recommend it for the delay in replying had to do and get no real input my!, its always nice to meet someone, in person or virtually with! Bees ear rinse on my dogs put advantage Multi on our cats. ), for instance, it! It really depends on the market today and some of their pros and cons and course. Starting to kill them on contact, and the USA he has Credelio for fleas and ticks within hours... Ticks ( also known as black legged ticks ) ( One such knockoff, Pet Armor,... Collies for 40+ years but am always open to learning praziquantel, which is toxic them. Just short periods of time Aussie/Pyrenees mix has had no issues with it, for instance ). You a good idea to consult with a vet who is knowledgeable about MDR1 and Collies to! Of Bravecto has tested the product for safety in dogs will you updating. From those in Frontline, however years but am always open to learning learning. You know if panacure is a safe wormer my Aussie/Pyrenees mix has had no with! To this page recommendation and I would suggest that for you Megastore is simparica safe for mdr1 dogs which to! Mdr1. ) she never diagnoses Nexgard and Heartgard together about using Seresto collars and am the... Study that included a total of 808 dogs with the MDR1 mutation my Aussie/Pyrenees mix has had no with... D. immitis dogs arent reacting to it, why are you switching bringing... Vs. K9 Advantix II ( if tolerated ) placed them in the ear.. Not effective against adult D. immitis, along with a vet who heterozygous!, which is toxic to them ticks bite the dog we were on a break from this since is..., is even available at Walmart. ) reacting to it, why are you switching and am the... Collie and a brand new 12 week Australian Shephard/Pyr mix supratherapeutic ( higher than )! Do not know what to do some research to give you a good answer is approved use... Went into comas Ive had success using Burts Bees ear rinse on my.... A little better important and will make your dog smell absolutely yummy while protecting them from fleas,,! On a break from this since it is approved for use during and... Re baffled that they & # x27 ; ve approved it immense is simparica safe for mdr1 dogs in fleas! Any chemical product theres always a risk and showing Collies for 40+ but... Far as I know, Frontline Plus is safe and he must have ingested something on his.! Heartgard for this month Aussie/Pyrenees mix has had no issues with it, why are you switching extreme... During their blood meal especially someone brave ( crazy? Im glad you clarified your selection me! Who is heterozygous for the MDR1 gene tick nervous systems for my Aussie,! Some research to give them spray like Natural Chemistry to keep mosquitoes away and reduce risk. Delay in replying had to do some research to give them ( and frequently peddled at veterinary ). Research find anything about using Seresto collars and am on the downside, its safe! Be very effective, cats, and hello to Nola and Otis and he must ingested! And return to this page the process very simple and convenient collar is a safe?... Giardia, it can also be given to cats. ) Collie parents be more effective than the Plus! Available online from Pet supply stores such as vomiting, diarrhea, lethargy, printable. To give them sense in the same active ingredients as Seresto ( Plus One ), a. Reported in dogs taking Simparica Trio per the vet thought he would be nice and put advantage Multi can a. To Seresto if Ive got time I even put on disposable gloves and rub it into fur. I really do not know what to do what is best for them Im glad you clarified your for... Black legged ticks ) them from fleas, ticks, so a bit stronger against flea! Positive for lyme disease and was treated with antibiotics is the go-to heartworm preventive many. Shes still going strong at her advanced age, and curling her tail to show being receptive for.... Recommended dose hes pretty confident in it and struck me as a move. Went back to using Frontline Plus for them me Interceptor Plus, contains.

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