Participants randomized to this group will receive daily placebo and health education lectures weekly for six months. Micardis (telmisartan) is an angiotensin II receptor antagonist used to treat high blood pressure (hypertension).Micardis is sometimes given together with other blood pressure medications. Telmisartan (brand name Micardis) is an angiotensin II receptor antagonist (angiotensin receptor blocker, ARB) used in the management of hypertension. Major medical illness including renal disease requiring dialysis, lung disease requiring oxygen, Parkinson's disease, a life-threatening illness with life expectancy less than six months, or cancer requiring treatment in the previous two years. Telmisartan (Micardis) is a high blood pressure medicine that researchers are evaluating as a possible treatment for Alzheimer’s disease.. As a cardiovascular disease therapy, it works by lowering blood pressure in vessels feeding the heart. Telmisartan shows antihypertensive and several pleiotropic effects that interact with metabolic pathways. What Is Micardis? We'd love to know more about you so we can deliver the most relevant content. Yet few effective therapies have been identified to help patients with PAD improve their walking impairment or prevent mobility loss. Pharmacy Taking Micardis (telmisartan) to treat your high blood pressure, or hypertension, can lower your heart rate, but it is not a common side effect unless you sweat heavily while exercising. Methods: It is a multicenter, prospective, double-dummy randomized controlled trial. Information provided by (Responsible Party): The TELEX trial will establish whether telmisartan alone improves walking performance in people with peripheral artery disease (PAD). Why Should I Register and Submit Results? Telmisartan 40 MG Tablet is used to treat high blood pressure, prevent stroke and other heart diseases. It works by blocking the action of certain natural substances that tighten the blood vessels, allowing the blood to flow more smoothly and the heart to pump more eff… Stopped telmisartan, PVC's resolved in about 7-10 days. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions. A consequence of this is increased oxidative capacity of Type II muscle fibers, which may be called “switching” from Type IIb to Type IIa. National Heart, Lung, and Blood Institute (NHLBI). To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Does Telmisartan Interact with other Medications? Finally, potential participants with a history of lower extremity revascularization who do not meet the criterion above and have an ABI > 0.90 with a 20% or higher drop in ABI after heel-rise exercise will be eligible. U.S. Department of Health and Human Services. Telmisartan is used alone or in combination with other medications to treat high blood pressure. Changes in vision 2. dizziness, lightheadedness, or fainting 3. fast heartbeat 4. large hives 5. painful urination or changes in urinary frequency 6. swelling in the hands, lower legs, and feet PAD will be defined as follows. It works by blocking a substance in the body that causes blood vessels to tighten. Based on promising preliminary evidence, we hypothesize that telmisartan, an oral angiotensin receptor blocker, will improve walking ability and prevent functional decline in people with PAD. What is telmisartan (Micardis), and what similar drugs are available? ClinicalTrials.gov Identifier: NCT02593110, Interventional COVID-19 is an emerging, rapidly evolving situation. Participants in this group will receive daily telmisartan and attend weekly educational lectures at the medical center for six months. Participants who only use oxygen at night may still qualify.]. Participants will have their dose increased to up to 80 mg as tolerated. Take telmisartan at the same time of day. TELEX is a randomized controlled clinical trial (2 x 2 factorial design) of 112 participants with PAD randomized to one of four arms: Group A: telmisartan + supervised exercise therapy; Group B: telmisartan + a "no exercise" control group; Group C: placebo + supervised exercise therapy; and Group D: placebo + a "no exercise" control group. This study examined the antihypertensive effect and potential exercise benefit of the angiotensin II receptor antagonist losartan when taken at altitude. Telmisartan is also used to decrease the chance of heart attack, stroke, or death in people 55 years of age or older who are at high risk for cardiovascular disease. Studies of telmisartan in this setting do not exclude that it may not preserve a meaningful fraction of the effect of the ACE i nhibitor to which it was compared. Above or below knee amputation, critical limb ischemia, wheelchair confinement, inability to walk without a walker, or current foot ulcer. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. Telmisartan has a biochemical effect on muscle cells which is very similar to the effect of exercise. In the present study we tested the hypothesis that telmisartan prevents adipogenesis in vitro and weight gain in vivo through activation of peroxisome proliferator-activated receptor (PPAR)-δ–dependent pathways in several tissues. Individual Participant Data (IPD) Sharing Statement: Six-minute walk performance [ Time Frame: Change from baseline to six-month follow-up ], Maximal treadmill walking distance [ Time Frame: Change from baseline to six-month follow-up ], Walking Impairment Questionnaire (WIQ) [ Time Frame: Change from baseline to six-month follow-up ], SF-36 Physical Functioning score [ Time Frame: Change from baseline to six-month follow-up ], Calf muscle biopsy measures [ Time Frame: Change from baseline to six-month follow-up ]. 1. Objective Altitude-related and exercise-related elevations in blood pressure (BP) increase the likelihood of developing pulmonary hypertension and high-altitude illness during high-altitude sojourn. Behavioral: Supervised Treadmill Exercise Therapy. [NOTE: potential participants may still qualify if they have had treatment for an early stage cancer in the past two years and the prognosis is excellent. 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